Memantine for late‐life depression and apathy after a disabling medical event: a 12‐week, double‐blind placebo‐controlled pilot study † Eric J. Lenze Department of Psychiatry, Washington University, St. … I am considering using Memantine (at 10mg/day) during a simultaneous Nicotine and Opioid withdrawal. It's worth noting I have never experienced nausea from Memantine, possibly due to the 5-HT3 antagonism. I may be an outlier with medical significance but if there's even one other person who finds it as beneficial as I do then I'm more than happy to share whatever information I can on Memantine. So that was something. Memantine. New comments cannot be posted and votes cannot be cast. How often do you use Memantine for depression? actually that Memantine prevents the Ca2+ signal from spiking and essentially this is the mechanism that prevents drug tolerance from developing Its name is derived from its structure; 3,5-dimethyladamantan-1-amine. Memantine was tapered up to 20 mg and down to 0 mg over 6 days. But there will be a certain foggy headedness to it, due to its effect on nicotinic receptors. Psychonautwiki founder here, you did an amazing job on the mementine article dude. You need to leave yourself at least 12 hours before you want to sleep before dosing. Although the half life of Memantine in your body is around 80 hours, the subjective effects are somewhere closer between 12-24 hours, and can be reduced with the acidification of your urine, increasing it's excretion rate. I'm super happy I'm not the only one around here using it like this. Its core structure is adamantane, a diamondoid of four interlocked cyclohexane rings in a stable 3-dimensional lattice conformation. I had structures I could interact with in the 3D world, put my arm behind and have my vision of my arm disappear but still being fully aware of the room I was in. Also, while combining a nicotine patch with memantine, I was very focused. Memantine isn't very long term memory impairing, in comparison to DXM, or even Ketamine, but short term memory does seem to suffer a bit and you can lose trains of thought quite easily at high doses. Eventually, this study was ceased and smoking should only be considered when modafinil is prescribed, especially among people with psychiatric conditions that have high comorbidity with nicotine dependence. Although doses will vary from person to person, I believe most beginner users would do well with 50mg as a starting recreational dose. Structures and voids are very apparent in low light and I would argue go beyond level 4. Memantine will help relieve you of the hyperexcitation of the the nmda circuit that will go bonkers when you quit taking opiates. Visually fairly similar to ketamine, but more controllable. currently, memantine, aniracetam & deprenyl is very effective. In addition to its glutamatergic modulation, memantine also acts as an agonist at the D2 and nicotinic acetylcholinergic receptors (nAChR). The NMDA agonist is known within the Kratom community as a way to lower tolerance. No sweating, over heating, or other common effects from stimulants, possibly due to how mild it's stimulant effects are (for me). It still needs a little tidying up which i will get to over the next couple of days but i just wanted to say thank you. Does it have any effects on the nicotinic receptors? Click here to read the full article @ The European respiratory journal Thanks for the thorough reply. The tropane ring of RTI-11 is substituted with a carbomethoxy group, also found in cocaine. And personally I enjoy it a lot. I feel very clear-headed on memantine. If you over shoot it, it's a very long time to endure it. Additional information on Memantine can be found: https://psychonautwiki.org/wiki/Memantine, https://www.erowid.org/pharms/memantine/memantine.shtml, Edit: If you've found this post recently, I've made a follow up post, answering some of the frequently asked questions I was receiving after making this post HERE. By using our Services or clicking I agree, you agree to our use of cookies. D-145; DRG-0267; Pharmacology Indication. As dietary supplements, these are widely available as well as legal nootropics in the U.S.A.. You can buy nootropics in stores or online without a prescription. T… Memantine also is a Dopamine D2 agonist, a non-competitive Serotonin 5-HT3 antagonist, a non-competitive nAChRs antagonist with similar potencies to NMDA antagonism and the Sigma σ1 receptor with potentially negligible activity. I have used ketamine in the past with the intention of helping depression and it was very pleasant at the time. Press question mark to learn the rest of the keyboard shortcuts. Although I cannot back up this claim with empirical evidence, Memantine is potentiated by Cannabis. Depth perception is by far the biggest impacted sense, and in low light settings will make the room you're in feel like its constantly moving between being a cathedral in size to a shoebox. Mild potentiaition occurs but otherwise I haven't found a way to describe exactly what changes, it is a fairly unique experience. Many nootropics with the very best proof and also noteworthy impact come from natural herbs, amino acids, vitamins, and also other natural materials. It produces an amazing unique physical euphoria, even in low doses, it's very clear headed, and the visuals are somewhat unique, although I cannot compare it to dissociatives other than Ketamine, DXM & Nitrous. How long do the effects last? Looks like you're using new Reddit on an old browser. Functional enough to play games like Overwatch and keep up with it without any struggle. Euphoria is more and more present, but loss of fine and gross motor control becomes more apparent. Take care and go up slowly on the memantine. The first week I was trialing it, I remember comparing the effects to that of Valium to my doctor and he seemed surprised by how well it was working. We promote harm reduction and fight against the drugs stigma. How much does it help? Mine does shortly up to the point I'm about to make as well, so no judgment. The one time I've combined LSD and a recreational dose of Memantine was one of the single most euphoric experiences I've ever had. You can drink cranberry juice to acidify your urine throughout your trip to shorten it's duration, avoid citrus and other foods that basify your urine. I don't think it's for everyone, but it certainly has enough merit for those who like dissociatives to try. And for the most part I'm perfectly functional cognivitely. Super Sour Ketamine is what I would describe the taste as. I could see some thereputic use in this because of it's functionality and long half life. It is formed when arginine is decarboxylated by the enzyme arginine decarboxylase and is found naturally in ragweed pollen, ergot fungi, octopus muscle, herring sperm, sponges, and the mammalian brain. Thanks again dude. To me I'd describe it as similar physical euphoria to a high 2nd plateau/low 3rd plateau DXM, and similar emotional effects, but without the mindfuck that DXM can cause. Methylecgonidine as the direct precursor to this compound. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.. Galantamine can cause serious skin reactions. Tobacco (most likely the nicotine, but I haven't ingested pure nicotine) also changes the subjective experience of Memantine, although only briefly. If I had to guess a hole is possible, but due to to the stimulatory effects I haven't been brave enough to push further than 250mg. Memantine and cerestat produced complete inhibition of ACh‐induced inward currents with affinities similar to that reported for native NMDA receptors. Galantamine side effects. Cholinesterase inhibitors may be added to memantine for further beneficial effects on behavioral symptoms and other … Low light settings let the visuals take hold much better and in complete darkness even 100mg may produce visuals on par with high Ketamine doses (for me high constitutes 200mg+), in a respective setting. In high doses I found memantine to be a somewhat generic dissociative although it did have some psychedelic style visuals which was a little unusual. Mild potentiaition occurs but otherwise I haven't found a way to describe exactly what changes, it is a fairly unique experience. Nicotine’s effects on the acetylcholine system means that it could have a significant positive effect on memory and recall. Well dang, I'll have to figure out what my dose would be like (considering I have a dissociative tolerance currently). Memantine's suggested neuroprotective effect 2,8 may also increase brain levels of the neuronal marker, N-acetyl aspartate (NAA).Because NAA is found primarily on neuronal axons in the brain, 9 perhaps the neuroprotective effect of memantine can be measured by quantifying the change in NAA concentrations in brain tissue via magnetic resonance spectroscopy. Memantine (Namenda®) is an uncompetitive NMDA receptor antagonist most commonly used in the management of moderate-to-severe Alzheimer’s disease. But if you like dissociatives like DXM/Ketamine, I think it's definitely worth trying. Atropine and hyoscine, as it greatly agitates my opioid withdrawal used Ketamine in the subjective effects section side-effects... 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